Cleanrooms play a vital role in many life sciences projects, and choosing the right construction system is crucial for both the building's functionality and long-term operations.

In today's challenging fiscal environment, every dollar counts, from early construction costs to ongoing maintenance expenses.

Mike Marston, DPR Construction’s Life Sciences Core Market Co-Leader, compares the importance of the right cleanroom construction system to a signature musician in a band. "I could compare it to the way a signature musician is key to the sound of one of my favorite rock bands," Marston said. "Just as signature musicians and the way they play are a cornerstone to creating the sound and experience they’re aiming for, cleanroom construction approaches play the same role in the success of a larger life sciences research or manufacturing facility."

While the final cleanroom may seem like the end goal, Marston and his team emphasize the importance of selecting the appropriate system, as it can significantly affect project speed, adjacent space impacts, and long-term facility maintenance. Factors such as project size, facility type, location, and market conditions also influence the choice.

“Project teams need to compare each cleanroom system as it applies to their individual projects, minding those variables, to determine which approach is best,” Marston said.

There are four primary cleanroom systems, each with distinct advantages:

Stick-built‍

The traditional construction method, where all materials are delivered to the site and built in stages.

Prefabricated/panelized‍

Wall and ceiling panels are built off-site and installed when conditions are right.

Modules‍

Fully-built cleanrooms, including structural elements and systems, are delivered and installed in place.

Podular‍

Prefabricated pods with finished walls, ceilings, and potential building systems.

Choosing the right cleanroom system requires answering several key questions, such as the local labor market, proximity to existing operational spaces, and the required speed-to-market.

For example, Marston shared, “A recent discussion with one of our clients is a great example of putting this approach to work... The resulting solution was an independently floor-supported mechanical mezzanine to carry the HVAC equipment with pods inserted underneath the walkable platforms.”

Ultimately, the right cleanroom system depends on the specifics of each project, with careful planning and early engagement ensuring successful construction and long-term operations.